Effect of 8 Weeks Aerobic Exercises and Green Coffee Supplement on Serum Myonectin, Meteorin-like, and Insulin Resistance in Obese Women

  Background and purpose: The purpose of this research was to compare the effects of aerobic exercises and green coffee consumption as a supplement on serum meteorin-like, myonectin level, and insulin resistance in obese women in Isfahan, Iran. Materials and methods: A clinical trial was performed in 40 women who were randomly divided into four groups, including aerobic exercises (5 sessions per week/30-45 min/ 8 weeks), green coffee supplement (400 mg/daily), aerobic exercises (5 sessions per week/30-45 min/ 8 weeks) and green coffee supplement (400 mg/ 8 weeks), and control groups. Forty eight hr after the last exercise session, blood samples were collected (after a 12-hr overnight fast) to measure the serum meteorin-like, myonectin, insulin, and glucose levels. Data analysis was done applying dependent t-test and ANOVA. Results: The participants’ mean weight, height, and BMI were 81.71±6.79 kg, 161.01±6.72 cm, and 32.4±4.6, respectively. ANOVA test showed significant differences in serum levels of myonectin (P=0.001), meteorin-like (P= 0.007), insulin (P = 0.005), fasting glucose (P= 0.001) and insulin resistance (P=0.001) between the groups studied. Aerobic exercises and green coffee intake significantly increased serum myonectin and meteorin-like levels, compared to aerobic exercises (P= 0.001) and green coffee consumption alone (P= 0.001). Conclusion: Green coffee intake and periodic exercises can affect some glycemic indices. Current study confirms the role of serum meteorin-like and myonectin level in preventing obesity and insulin resistance.   (Clinical Trials Registry Number: IRCT20170510033909N5)